Commentary: Mendelian randomization and women’s health
نویسندگان
چکیده
منابع مشابه
Commentary: Mendelian Randomization, 18 years on.
I have no notes left regarding writing ‘Apolipoprotein E isoforms, serum cholesterol, and cancer’,1 but I think I thought it up in Hawaii. I passed through Hawaii on my way to the US from Melbourne, where I had given a talk on diet, low cholesterol, and cancer at the 7th International Atherosclerosis Symposium in October 1985. At that time the dangers of a low serum cholesterol level was a hot ...
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A et al. Body mass index and lung cancer risk: results from the ICARE study, a large, population-based case-control study. A et al. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose-response meta-analysis of prospective studies. Association of oral contraceptive use,...
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Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization, the random assortment of genes from parents to offspring that occurs during gamete formation and conception provides one method for assessing the causal nature of so...
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Background The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of ge...
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Gallstonedisease causes a substantialhealthandeconomicburden in theUnited States andother developed countries.More than 6millionmen and 14millionwomen aged 20 to 74 years in the United States have gallbladder disease.1 Approximately 650 000 to 700 000 cholecystectomies are performed annually in the United States, and the costs associated with the symptoms and complications of gallstones are est...
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ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2019
ISSN: 0300-5771,1464-3685
DOI: 10.1093/ije/dyz141